| Week 1 | ||||
| Thu, Sep. 8 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SD 43 at LA 37 | Final | SD Douglas Knotts 322 yds. | SD Earl Wregget 229 yds. | SD Earl Wregget 135 yds. |
| Sat, Sep. 10 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ARI 24 at NO 26 | Final | NO Chris Coy 266 yds. | NO Austin Thomas 167 yds. | NO Jacob Mallory 113 yds. |
| Sun, Sep. 11 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 20 at NY 21 | Final | DET Brandon Peters 269 yds. | NY Sherwood Brown 174 yds. | DET Patrick Allen 71 yds. |
| BRO 20 at BOS 10 | Final | BRO Logan Fisher 262 yds. | BRO Jordan Ellis 111 yds. | BRO Keith Davis 108 yds. |
| MIL 10 at WAS 33 | Final | WAS Austin McNiel 331 yds. | WAS Justice Hill 120 yds. | WAS Marcus Liberty 117 yds. |
| MIA 23 at TB 28 | Final | TB Calvin Ayre 306 yds. | TB Cedric Miles 110 yds. | TB Wallace Poole 141 yds. |
| CHI 18 at PHI 13 | Final | CHI Ryan Gable 213 yds. | CHI B.J. MacIntyre 165 yds. | CHI B.J. MacIntyre 66 yds. |
| HOU 21 at PIT 33 | Final | PIT Tommy Reese 328 yds. | PIT Madre London 155 yds. | PIT Madre London 122 yds. |
| MIN 34 at TEN 20 | Final | MIN Thomas Kaye 341 yds. | MIN Charles Hyder 149 yds. | MIN Domino Jenkins 153 yds. |
| CAR 24 at IND 20 | Final | CAR John Locke 261 yds. | CAR Paul Perkins 143 yds. | CAR Paul Perkins 77 yds. |
| LV 25 at STL 21 | Final | LV Brendan Cyr 242 yds. | LV Ise Smith 163 yds. | LV Jamal Weekes 129 yds. |
| ATL 34 at COL 28 | Final | ATL Ryan Glassman 324 yds. | ATL Chris L. Tucker 118 yds. | ATL Mike Martinez 126 yds. |
| CIN 24 at SEA 31 | Final | SEA Raymond Berry 252 yds. | SEA Bennett James 127 yds. | SEA Tyler Lockett 89 yds. |
| CLE 20 at KC 41 | Final | KC Thaddeus Lewis 389 yds. | KC Jordan Morris 170 yds. | KC Andrew Pierce 126 yds. |
| Mon, Sep. 12 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CAL 17 at BAL 31 | Final | BAL Randy Carlysle 346 yds/ | BAL Tim Harper 122 yds. | BAL Robert Gallo 115 yds. |
| BUF 51 at DAL 23 | Final | BUF Kyle Allen 436 yds. | BUF Justin Jonas 108 yds. | BUF Miles Dixon 177 yds. |
| Week 2 | ||||
| Thu, Sep. 15 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ARI 24 at TB 37 | Final | TB Calvin Ayre 360 yds. | TB Cedric Miles 87 yds. | TB Otis Glendale 134 yds. |
| Sun, Sep. 18 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| WAS 29 at CAR 24 | Final | WAS Austin McNiel 265 yds. | WAS Justice Hill 68 yds. | WAS Marcus Kemp 93 yds. |
| BOS 24 at MIA 38 | Final | MIA Adam Murray 339 yds, | MIA Darnell Sullivan 68 yds. | MIA Devin Youngblood 152 yds. |
| DAL 24 at ATL 20 | Final | DAL Adam Froman 221 yds. | DAL Jevon Jones 66 yds. | DAL Jevon Jones> 74 yds. |
| NY 22 at CLE 17 | Final | NY Richard Shoemann 222 yds. | NY Sherwood Brown 89 yds. | NY Henry Rawlins 87 yds. |
| PHI 22 at DET 36 | Final | DET Brandon Peters 308 yds. | DET Gary Brightwell 80 yds. | DET Dontario Drummond 162 yds. |
| BAL 28 at CIN 27 | Final | BAL Randy Carlysle 223 yds. | BAL Tim Harper 56 yds. | BAL Charles Hunt 72 yds. |
| BRO 31 at CHI 30 | Final | BRO Logan Fisher 277 yds. | BRO Jordan Ellis 88 yds. | BRO Keith Davis 105 yds. |
| BUF 34 at MIN 24 | Final | BUF Kyle Allen 330 yds. | BUF Justin Jonas 77 yds. | BUF Miles Dixon 104 yds. |
| STL 24 at HOU 0 | Final | STL Jayden Daniels 241 yds. | STL Jayden Daniels 67 yds. | STL Kennedy Lewis 12 yds. |
| PIT 9 at COL 16 | Final | COL Brandon Morris 199 yds. | COL Omni Wells 63 yds. | COL Demarcus Robinson 75 yds. |
| NO 26 at LV 25 | Final | NO Chris Coy 228 yds. | NO Austin Thomas 74 yds. | NO Jailyn Marshall 83 yds. |
| IND 3 at SEA 20 | Final | SEA Raymond Berry 207 yds. | SEA Bennett James 48 yds. | SEA Tyler Lockett 62 yds. |
| SD 20 at CAL 30 | Final | CAL Travis Wilson 266 yds. | CAL Micah Mason 85 yds. | CAL Micah Mason 120 yds. |
| KC 36 at MIL 27 | Final | KC Thaddeus Lewis 276 yds. | KC Jordan Morris 143 yds. | KC Kevin Kroger 122 yds. |
| Mon, Sep. 19 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LA 31 at TEN 20 | Final | LA Rayce Dawson 314 yds. | LA Rashard Jackson 56 yds. | LA Jayar Jackson 88 yds. |
| Week 3 | ||||
| Thu, Sep. 22 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CAL 27 at NO 13 | Final | CAL Travis Wilson 223 yds. | CAL Micah Mason 197 yds. | CAL Courtney Smith 106 yds. |
| Sun, Sep. 25 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PIT 20 at NY 27 | Final | NY Richard Shoemann 233 yds. | NY Sherwood Brown 152 yds. | NY Draymond Blackshear 133 yds. |
| BAL 24 at CAR 17 | Final | BAL Randy Carlysle 262 yds. | BAL Tim Harper 104 yds. | BAL Robert Gallo 116 yds. |
| CIN 18 at PHI 30 | Final | PHI Sylvester James 280 yds. | PHI Sylvester James 86 yds. | PHI Jaydon Thompson 113 yds. |
| LA 24 at MIA 33 | Final | MIA Adam Murray 257 yds. | MIA Darnell Sullivan 103 yds. | MIA Devin Youngblood 107 yds. |
| BRO 31 at ATL 26 | Final | BRO Logan Fisher 287 yds. | BRO Jordan Ellis 136 yds. | BRO Keith Davis 109 yds. |
| WAS 22 at IND 28 | Final | IND Scott Tolzner 234 yds. | IND D.J. Oats 77 yds. | IND Roy Roberts 83 yds. |
| LV 18 at CHI 25 | Final | CHI Ryan Gable 241 yds. | CHI Elliott Boone 122 yds. | CHI Elliott Boone 79 yds. |
| CLE 20 at MIL 34 | Final | MIL Richard Adams 312 yds. | MIL Kay'Ron Adams 146 yds. | MIL Greg Chatham 157 yds. |
| COL 17 at STL 28 | Final | STL Jayden Daniels 260 yds. | STL Jayden Daniels 78 yds. | STL Kennedy Lewis 112 yds. |
| BOS 20 at KC 31 | Final | KC Thaddeus Lewis 314 yds. | KC Jordan Morris 122 yds. | KC Kevin Kroger 118 yds. |
| SEA 24 at DAL 28 | Final | DAL Adam Froman 246 yds. | DAL Jevon Jones 74 yds. | DAL Martin Turner 85 yds. |
| HOU 15 at ARI 27 | Final | ARI Jon Fallon 250 yds. | ARI Otis Harper 69 yds. | ARI Marvin MacDonald 81 yds. |
| MIN 30 at SD 23 | Final | MIN Thomas Kaye 288 yds. | MIN Charles Hyder 166 yds. | MIN Domino Jenkins 147 yds. |
| TEN 30 at DET 28 | Final | TEN Ben Bryant 268 yds. | TEN R.J. Cash 146 yds. | TEN James Roe 127 yds. |
| Mon, Sep. 26 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TB 22 at BUF 30 | Final | BUF Kyle Allen 307 yds. | BUF Justin Jonas 75 yds. | BUF Marcus Floyd 129 yds. |
| Week 4 | ||||
| Thu, Sep. 29 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CAL 28 at MIA 34 | Final (ot) | MIA Adam Murray 334 yds. | MIA Darnell Sullivan 107 yds. | MIA Devin Youngblood 128 yds. |
| Sun, Oct. 2 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 35 at BRO 38 | Final (ot) | BRO Logan Fisher 328 yds. | BRO Jordan Ellis 115 yds. | BRO Keith Davis 124 yds. |
| CHI 23 at BAL 20 | Final | CHI Ryan Gable 244 yds. | CHI Ryan Gable 41 yds. | CHI B.J. MacIntyre 87 yds. |
| BUF 24 at WAS 17 | Final | BUF Kyle Allen 233 yds. | BUF Justin Jonas 82 yds. | BUF Marcus Floyd 77 yds. |
| NY 24 at CIN 28 | Final | CIN Kevin Hogan 237 yds. | CIN Kenyon Barnes 114 yds. | CIN J.J. Jefferson 126 yds. |
| PHI 40 at MIN 27 | Final | PHI Sylvester James 362 yds. | PHI Sylvester James 67 yds. | PHI Jaydon Thompson 178 yds. |
| COL 19 at NO 17 | Final | COL Brandon Morris 221 yds. | COL Omni Wells 65 yds. | COL Demarcus Robinson 77 yds. |
| CAR 20 at SD 26 | Final | SD Douglas Knotts 276 yds. | SD Earl Wregget 80 yds. | SD Kyi Wright 110 yds. |
| ATL 31 at LA 27 | Final | ATL Ryan Glassman 318 yds. | ATL Chris L. Tucker 140 yds. | ATL Mike Martinez 136 yds. |
| BOS 26 at PIT 21 | Final | BOS Vance Becker 232 yds. | BOS Vance Becker 26 yds. | BOS Wesley Matthews 87 yds. |
| Mon, Oct. 3 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ARI 19 at DAL 27 | Final | DAL Adam Froman 244 yds. | DAL Jevon Jones 129 yds. | DAL Jevon Jones 137 yds. |
| Week 5 | ||||
| Thu, Oct. 6 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BUF 28 at BOS 17 | Final | BUF Kyle Allen 307 yds. | BUF Justin Jonas 86 yds. | BUF Miles Dixon 115 yds. |
| Sun, Oct. 9 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| HOU 28 at NY 17 | Final | HOU Waylon Springer 218 yds. | HOU Milo Hall 159 yds. | HOU Milo Hall 73 yds. |
| KC 34 at ATL 17 | Final | KC Thaddeus Lewis 304 yds. | KC Jordan Morris 118 yds. | KC J.J. Reed 130 yds. |
| CAL 34 at IND 17 | Final | CAL Travis Wilson 321 yds. | CAL Micah Mason 134 yds. | CAL David Wesley 146 yds. |
| CLE 40 at CHI 6 | Final | CLE De'Andre Johnson 366 yds. | CLE Kelvin Diggs 114 yds. | CLE Alex Johnson 189 yds. |
| BRO 27 at MIL 20 | Final | BRO Logan Fisher 267 yds. | BRO Jordan Ellis 88 yds. | BRO Keith Davis 133 yds. |
| STL 10 at DAL 27 | Final | DAL Adam Froman 244 yds. | DAL Jevon Jones 109 yds. | DAL Jevon Jones 118 yds. |
| CAR 18 at LV 23 | Final | LV Brendan Cyr 222 yds. | LV Ise Smith 97 yds. | LV Jamal Weekes 83 yds. |
| TB 23 at SEA 21 | Final | TB Calvin Ayre 236 yds. | TB Cedric Miles 58 yds. | TB Wallace Poole 69 yds. |
| Mon, Oct. 10 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TEN 20 at NO 31 | Final | NO Chris Coy 310 yds. | NO Austin Thomas 94 yds. | NO Jailyn Marshall 120 yds. |
| Week 6 | ||||
| Thu, Oct. 13 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SEA 27 at MIA 31 | Final | MIA Adam Murray 314 yds. | MIA Darnell Sullivan 86 yds. | MIA Devin Youngblood 147 yds. |
| Sun, Oct. 16 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CIN 27 at WAS 18 | Final | CIN Kevin Hogan 244 yds. | CIN Kenyon Barnes 121 yds. | CIN J.J. Jefferson 113 yds. |
| TB 20 at PHI 26 | Final | PHI Sylvester James 266 yds. | PHI Jaydon Thompson 51 yds. | PHI Jaydon Thompson 104 yds. |
| MIN 30 at CLE 23 | Final | MIN Thomas Kaye 278 yds. | MIN Charles Hyder 123 yds. | MIN Domino Jenkins 126 yds. |
| IND 13 at DET 48 | Final | DET Brandon Peters 379 yds. | DET Gary Brightwell 182 yds. | DET Roy Roberts 242 yds. |
| PIT 22 at TEN 17 | Final | PIT Tommy Reese 226 yds. | PIT Madre London 55 yds. | PIT Nick Hill 67 yds. |
| BAL 17 at STL 23 | Final | STL Jayden Daniels 242 yds. | STL Jayden Daniels 46 yds. | STL Kennedy Lewis 88 yds. |
| HOU 20 at COL 14 | Final | COL Brandon Morris 222 yds. | HOU Milo Hall 68 yds. | HOU Jordan Higgins 71 yds. |
| LA 28 at LV 17 | Final | LA Rayce Dawson 260 yds. | LA Rashard Jackson 45 yds. | LA Taiwan Jones 83 yds. |
| SD 28 at MIL 10 | Final | SD Douglas Knotts 270 yds. | SD Earl Wregget 72 yds. | SD Kyi Wright 103 yds. |
| Mon, Oct. 17 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| KC 23 at ARI 24 | Final | ARI Jon Fallon 267 yds. | ARI Otis Harper 93 yds. | ARI Marvin MacDonald 96 yds. |
| Week 7 | ||||
| Thu, Oct. 20 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CIN 20 at BOS 29 | Final | BOS Vance Becker 261 yds. | BOS Wesley Matthews 33 yds. | BOS Brian Lee 84 yds. |
| Sun, Oct. 23 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NY 31 at BUF 24 | Final | NY Ryan Gable 279 yds. | NY Sherwood Brown 118 yds. | NY B.J. MacIntyre 125 yds. |
| MIN 28 at BAL 30 | Final | BAL Randy Carlysle 278 yds. | BAL Tim Harper 113 yds. | BAL Robert Gallo 108 yds. |
| LA 26 at CAR 28 | Final | CAR John Locke 262 yds. | CAR Paul Perkins 74 yds. | CAR Paul Perkins 68 yds. |
| TEN 23 at TB 3 | Final | TEN Ben Bryant 224 yds. | TEN R.J. Cash 83 yds. | TEN Josiah Price 77 yds. |
| LV 36 at ATL 17 | Final | LV Brendan Cyr 304 yds. | LV Ise Smith 137 yds. | LV Jamal Weekes 118 yds. |
| WAS 21 at PIT 13 | Final | WAS Austin McNiel 229 yds. | WAS Justice Hill 76 yds. | WAS Marcus Kemp 81 yds. |
| PHI 23 at IND 17 | Final | PHI Sylvester James 233 yds. | PHI Sylvester James 44 yds. | PHI Jaydon Thompson 78 yds. |
| MIL 22 at CHI 28 | Final | MIL Richard Adams 266 yds. | MIL Kay'Ron Adams 84 yds. | MIL Dabney Myron 71 yds. |
| SD 21 at STL 17 | Final | SD Douglas Knotts 282 yds. | SD Earl Wregget 111 yds. | SD Daryll Kincaid 80 yds. |
| BRO 24 at HOU 20 | Final | BRO Logan Fisher 265 yds. | BRO Jordan Ellis 103 yds. | BRO Keith Davis 84 yds. |
| COL 14 at ARI 24 | Final | ARI Jon Fallon 263 yds. | ARI Otis Harper 81 yds. | ARI Marvin MacDonald 86 yds. |
| NO 14 at SEA 27 | Final | SEA Raymond Berry 213 yds. | SEA Bennett Jame 146 yds. | SEA Anthony Jones 70 yds. |
| KC 44 at CAL 27 | Final | KC Thaddeus Lewis 336 yds. | KC Jordan Morris 128 yds. | KC Kevin Kroger 166 yds. |
| DAL 18 at MIA 27 | Final | MIA Adam Murray 270 yds. | MIA Darnell Sullivan 114 yds. | MIA Devin Youngblood 119 yds. |
| Mon, Oct. 24 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 30 at CLE 28 | Final | DET Brandon Peters 281 yds. | DET Gary Brightwell 97 yds. | DET Roy Roberts 134 yds. |
| Week 8 | ||||
| Thu, Oct. 27 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BOS 29 at TEN 26 | Final (ot) | BOS Vance Becker 272 yds. | BOS Wesley Matthews 41 yds. | BOS Brian Lee 83 yds. |
| Sun, Oct. 30 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| IND 14 at NY 17 | Final | NY Ryan Gable 226 yds. | NY Sherwood Brown 93 yds. | NY Draymond Blackshear 74 yds. |
| CHI 10 at WAS 21 | Final | WAS Austin McNiel 232 yds. | WAS Justice Hill 67 yds. | WAS Geno Lewis 83 yds. |
| BAL 23 at BUF 22 | Final | BAL Randy Carlysle 242 yds. | BAL Tim Harper 117 yds. | BAL Robert Gallo 88 yds. |
| SD 24 at ATL 27 | Final (ot) | ATL Ryan Glassman 317 yds. | ATL Chris L. Tucker 122 yds. | ATL Dominique Worthy 136 yds. |
| PIT 15 at CIN 27 | Final | CIN Kevin Hogan 266 yds. | CIN Kenyon Barnes 67 yds. | CIN Tre Ellis 84 yds. |
| BRO 17 at MIN 29 | Final | MIN Thomas Kaye 272 yds. | MIN Charles Hyder 68 yds. | MIN Domino Jenkins 76 yds. |
| NO 37 at KC 34 | Final | NO Chris Coy 339 yds. | NO Austin Thomas 160 yds. | NO Jacob Mallory 178 yds. |
| CAR 20 at DAL 47 | Final | DAL Adam Froman 403 yds. | DAL Jevon Jones 126 yds. | DAL Antonio Tucker 145 yds. |
| SEA 23 at HOU 13 | Final | SEA Raymond Berry 212 yds. | SEA Bennett James 90 yds. | SEA Anthony Jones 61 yds. |
| ARI 20 at COL 24 | Final | COL Brandon Morris 222 yds. | COL Omni Wells 73 yds. | COL Jayson Lee 69 yds. |
| MIA 23 at LV 0 | Final | MIA Adam Murray 245 yds. | MIA Darnell Sullivan 105 yds. | MIA Devin Youngblood 87 yds. |
| STL 14 at CAL 27 | Final | CAL Travis Wilson 296 yds. | CAL Micah Mason 139 yds. | CAL Chester Purtan 140 yds. |
| TB 21 at LA 20 | Final | TB Calvin Ayre 220 yds. | TB Cedric Miles 65 yds. | TB Wallace Poole 71 yds. |
| MIL 17 at DET 27 | Final | DET Brandon Peters 268 yds. | DET Gary Brightwell 89 yds. | DET Roy Roberts 121 yds. |
| Mon, Oct. 31 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PHI 37 at CLE 21 | Final | PHI Sylvester James 339 yds. | PHI Paul Perkins 129 yds. | PHI Jaydon Thompson 127 yds. |
| Week 9 | ||||
| Thu, Nov. 3 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ATL 26 at NO 24 | Final | ATL Ryan Glassman 251 yds. | ATL Chris L. Tucker 97 yds. | ATL Mike Martinez 93 yds. |
| Sun, Nov. 6 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TEN 27 at BRO 31 | Final | BRO Logan Fisher 308 yds. | BRO Jordan Ellis 122 yds. | BRO Keith Davis 181 yds. |
| COL 8 at NY 24 | Final | NY Ryan Gable 266 yds. | NY Sherwood Brown 82 yds. | NY Draymond Blackshear 79 yds. |
| IND 3 at BOS 27 | Final | BOS Vance Becker 282 yds. | BOS Vance Becker 44 yds. | BOS Brian Lee 103 yds. |
| CLE 28 at BUF 27 | Final | CLE De'Andre Johnson 269 yds. | CLE Kelvin Diggs 83 yds. | CLE Pharoah Brown 87 yds. |
| ARI 20 at CAR 21 | Final | CAR John Locke 214 yds. | CAR John Locke 31 yds. | CAR Will Horton 65 yds. |
| HOU 0 at TB 17 | Final | TB Calvin Ayre 229 yds. | TB Cedric Miles 67 yds. | TB Wallace Poole 78 yds. |
| WAS 20 at PHI 30 | Final | PHI Sylvester James 303 yds. | PHI Paul Perkins 127 yds. | PHI Jaydon Thompson 111 yds. |
| CIN 42 at PIT 6 | Final | CIN Kevin Hogan 366 yds, | CIN Kenyon Barnes 149 yds. | CIN J.J. Jefferson 156 yds. |
| DET 29 at CHI 9 | Final | DET Brandon Peters 248 yds. | DET Gary Brightwell 109 yds. | DET Jake Upton 96 yds. |
| MIA 28 at MIN 30 | Final | MIN Thomas Kaye 241 yds. | MIN Charles Hyder 106 yds. | MIN Domino Jenkins 83 yds. |
| DAL 18 at KC 33 | Final | KC Thaddeus Lewis 317 yds. | KC Jordan Morris 128 yds. | KC Kevin Kroger 114 yds. |
| STL 27 at SEA 20 | Final | STL Jayden Daniels 260 yds. | STL Jayden Daniels 42 yds. | STL Kennedy Lewis 77 yds. |
| LV 20 at SD 21 | Final | SD Douglas Knotts 281 yds. | SD Earl Wregget 115 yds. | SD Kyi Wright 96 yds. |
| LA 27 at CAL 33 | Final | CAL Travis Wilson 312 yds. | CAL Micah Mason 122 yds. | CAL Courtney Smith 140 yds. |
| Mon, Nov. 7 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIL 17 at BAL 29 | Final | BAL Randy Carlysle 268 yds. | BAL Tim Harper 113 yds. | BAL Robert Gallo 84 yds. |
| Week 10 | ||||
| Thu, Nov. 10 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SEA 20 at KC 24 | Final | KC Thaddeus Lewis 260 yds. | KC Jordan Morris 82 yds. | KC J.J. Reed 93 yds. |
| Sun, Nov. 13 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LV 28 at BRO 34 | Final | BRO Logan Fisher 252 yds. | BRO Jordan Ellis 107 yds. | BRO Keith Davis 119 yds. |
| TB 24 at MIA 36 | Final | MIA Adam Murray 340 yds. | MIA Darnell Sullivan 116 yds. | MIA Devin Youngblood 144 yds. |
| COL 12 at CAR 26 | Final | CAR John Locke 261 yds. | CAR John Locke 41 yds. | CAR Barry Henderson 83 yds. |
| BUF 27 at PHI 34 | Final | PHI Sylvester James 318 yds. | PHI Paul Perkins 72 yds. | PHI Jaydon Thompson 186 yds. |
| PIT 20 at CLE 17 | Final | PIT Tommy Reese 235 yds. | PIT Madre London 77 yds. | PIT Madre London 63 yds. |
| BAL 20 at IND 23 | Final | IN Scott Tolzner 228 yds. | IN D.J. Oats 66 yds. | IN Dontario Drummond 85 yds. |
| NY 24 at MIL 27 | Final | MIL Richard Adams 291 yds. | MIL Kay'Ron Adams 71 yds. | MIL Dabney Myron 102 yds. |
| CHI 14 at TEN 23 | Final | TEN Ben Bryant 246 yds. | TEN R.J. Cash 118 yds. | TEN James Roe 77 yds. |
| WAS 20 at MIN 31 | Final | MIN Thomas Kaye 305 yds. | MIN Charles Hyder 112 yds. | MIN Domino Jenkins 143 yds. |
| DAL 24 at HOU 28 | Final | HOU Waylon Springer 214 yds. | HOU Milo Hall 46 yds. | HOU Milo Hall 66 yds. |
| ATL 7 at ARI 27 | Final | ARI Jon Fallon 264 yds. | ARI Otis Harper 71 yds. | ARI Kirby Moore 78 yds. |
| STL 24 at LA 23 | Final | STL Jayden Daniels 236 yds. | STL Jayden Daniels 50 yds. | STL Kennedy Lewis 67 yds. |
| CIN 16 at CAL 28 | Final | CAL Travis Wilson 259 yds. | CAL Micah Mason 138 yds. | CAL Chester Purtan 70 yds. |
| NO 20 at DET 33 | Final | DET Brandon Peters 318 yds. | DET Gary Brightwell 117 yds. | DET Jake Upton 125 yds. |
| Mon, Nov. 14 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SD 28 at BOS 16 | Final | SD Douglas Knotts 262 yds. | SD Earl Wregget 119 yds. | SD Kyi Wright 80 yds. |
| Week 11 | ||||
| Thu, Nov. 17 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ATL 17 at KC 34 | Final | KC Thaddeus Lewis 332 yds. | KC Jordan Morris 127 yds. | KC Kevin Kroger 149 yds. |
| Sun, Nov. 20 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PHI 28 at NY 27 | Final | PHI Sylvester James 267 yds. | PHI Paul Perkins 83 yds. | PHI Jaydon Thompson 114 yds. |
| BUF 23 at BRO 6 | Final | BUF Kyle Allen 231 yds. | BUF Justin Jonas 60 yds. | BUF Nick Hill 71 yds. |
| BAL 20 at BOS 29 | Final | BOS Vance Becker 216 yds. | BOS Vance Becker 33 yds. | BOS Brian Lee 67 yds. |
| CLE 10 at WAS 22 | Final | WAS Austin McNiel 238 yds. | WAS Justice Hill 79 yds. | WAS Marcus Liberty 76 yds. |
| NO 27 at CAR 13 | Final | NO Chris Coy 277 yds. | NO Austin Thomas 92 yds. | NO Josh Oliver 88 yds. |
| STL 20 at TB 24 | Final | TB Calvin Ayre 242 yds. | TB Cedric Miles 63 yds. | TB Wallace Poole 79 yds. |
| MIN 3 at PIT 28 | Final | PIT Tommy Reese 235 yds. | PIT Madre London 140 yds. | PIT Marcus Floyd 77 yds. |
| DET 34 at IND 26 | Final | DET Brandon Peters 319 yds. | DET Gary Brightwell 108 yds. | DET Roy Roberts 125 yds. |
| CHI 17 at MIL 24 | Final | MIL Richard Adams 248 yds. | MIL Kay'Ron Adams 113 yds. | MIL Greg Chatham 71 yds. |
| MIA 27 at HOU 6 | Final | MIA Adam Murray 226 yds. | MIA Darnell Sullivan 87 yds. | MIA Devin Youngblood 81 yds. |
| DAL 36 at COL 17 | Final | DAL Adam Froman 308 yds. | DAL Jevon Jones 129 yds. | DAL Jevon Jones 141 yds. |
| LV 29 at LA 20 | Final | LV Brendan Cyr 267 yds. | LV Ise Smith 142 yds. | LV Jamal Weekes 87 yds. |
| CAL 24 at SD 23 | Final | CAL Travis Wilson 239 yds. | CAL Micah Mason 76 yds. | CAL Courtney Smith 84 yds. |
| TEN 42 at CIN 29 | Final | TEN Ben Bryant 364 yds. | TEN R.J. Cash 124 yds. | TEN James Roe 136 yds. |
| Mon, Nov. 21 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SEA 24 at ARI 10 | Final | SEA Raymond Berry 214 yds. | SEA Bennett James 86 yds. | SEA Anthony Jones 69 yds. |
| Week 12 | ||||
| Thu, Nov. 24 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LA 14 at DET 38 | Final | DET Brandon Peters 387 yds. | DET Gary Brightwell 109 yds. | DET Patrick Allen 216 yds. |
| NO 17 at DAL 31 | Final | DAL Adam Froman 319 yds. | DAL Jevon Jones 124 yds. | DAL Leonardo Hughes 119 yds. |
| TB 27 at CAL 16 | Final | TB Calvin Ayre 258 yds. | TB Cedric Miles 103 yds. | TB Otis Glendale 87 yds. |
| Fri, Nov. 25 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PHI 31 at WAS 28 | Final | PHI Sylvester James 266 yds. | PHI Sylvester James 142 yds. | PHI Henry Krieger 79 yds. |
| Sat, Nov. 26 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TEN 28 at BAL 26 | Final | TEN Ben Bryant 234 yds. | TEN R.J. Cash 137 yds. | TEN James Roe 92 yds. |
| Sun, Nov. 27 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BOS 20 at BRO 28 | Final | BRO Logan Fisher 244 yds. | BRO Jordan Ellis 107 yds. | BRO Keith Davis 93 yds. |
| CLE 23 at NY 20 | Final (ot) | CLE De'Andre Johnson 236 yds. | CLE Kelvin Diggs 84 yds. | CLE Alex Johnson 78 yds. |
| ATL 20 at CAR 26 | Final (ot) | CAR John Locke 222 yds. | CAR John Locke 61 yds. | CAR Jamaal Gathers 69 yds. |
| IND 27 at CHI 13 | Final | IND Scott Tolzner 278 yds. | IND D.J. Oats 136 yds. | IND Tre Tipton 84 yds. |
| PIT 15 at MIN 36 | Final | MIN Thomas Kaye 339 yds. | MIN Charles Hyder 157 yds. | MIN Domino Jenkins 189 yds. |
| MIA 17 at STL 20 | Final (ot) | STL Jayden Daniels 234 yds. | STL Jayden Daniels 36 yds. | STL Kennedy Lewis 71 yds. |
| LV 28 at KC 24 | Final | LV Brendan Cyr 266 yds. | LV Ise Smith 135 yds. | LV Jamal Weekes 76 yds. |
| SEA 16 at COL 12 | Final | SEA Raymond Berry 182 yds. | SEA Bennett James 74 yds. | SEA Anthony Jones 46 yds. |
| HOU 20 at SD 31 | Final | SD Douglas Knotts 272 yds. | SD Earl Wregget 115 yds. | SD Kyi Wright 83 yds. |
| MIL 20 at ARI 30 | Final | ARI Jon Fallon 324 yds. | ARI Otis Harper 118 yds. | ARI Rashard Higgins 148 yds. |
| Mon, Nov. 28 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CIN 22 at BUF 26 | Final | BUF Kyle Allen 263 yds. | BUF Justin Jonas 82 yds. | BUF Marvin MacDonald 77 yds. |
| Week 13 | ||||
| Thu, Dec. 1 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 38 at DAL 27 | Final | DET Brandon Peters 362 yds. | DET Gary Brightwell 144 yds. | DET Roy Roberts 178 yds. |
| Sat, Dec. 3 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SD 38 at KC 44 | Final | KC Thaddeus Lewis 361 yds. | KC Jordan Morris 159 yds. | KC Kevin Kroger 173 yds. |
| Sun, Dec. 4 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NY 30 at WAS 28 | Final | NY Ryan Gable 303 yds. | NY Sherwood Brown 116 yds. | NY Draymond Blackshear 151 yds. |
| BRO 9 at BAL 10 | Final | BAL Randy Carlysle 188 yds. | BAL Tim Harper 54 yds. | BAL Robert Gallo 64 yds. |
| MIL 30 at PHI 26 | Final | MIL Richard Adams 249 yds. | MIL Kay'Ron Adams 68 yds. | MIL Matt Adams 85 yds. |
| MIN 28 at BUF 24 | Final | MIN Thomas Kaye 271 yds. | MIN Charles Hyder 114 yds. | MIN Josiah Price 83 yds. |
| COL 9 at TB 23 | Final | TB Calvin Ayre 235 yds. | TB Cedric Miles 42 yds. | TB Otis Glendale 66 yds. |
| TEN 25 at IND 10 | Final | TEN Chance Wharden 236 yds. | TEN R.J. Cash 81 yds. | TEN R.J. Cash 62 yds. |
| BOS 17 at CHI 13 | Final | BOS Vance Becker 233 yds. | BOS Wesley Matthews 38 yds. | BOS Howard Jenkins 70 yds. |
| LA 16 at NO 30 | Final | NO Chris Coy 244 yds. | NO Austin Thomas 69 yds. | NO Jailyn Marshall 67 yds. |
| HOU 6 at STL 26 | Final | STL Jayden Daniels 265 yds. | STL Jayden Daniels 48 yds. | STL Kennedy Lewis 83 yds. |
| PIT 20 at LV 17 | Final | PIT Tommy Reese 229 yds. | PIT Madre London 124 yds. | PIT Madre London 87 yds. |
| CAR 12 at SEA 33 | Final | SEA Raymond Berry 263 yds. | SEA Bennett James 88 yds. | SEA Tyler Lockett 116 yds. |
| ATL 20 at CAL 26 | Final | CAL Travis Wilson 224 yds. | CAL Micah Mason 173 yds. | CAL Micah Mason 104 yds. |
| MIA 17 at ARI 27 | Final | ARI Jon Fallon 260 yds. | ARI Otis Harper 74 yds. | ARI Kirby Moore 101 yds. |
| Mon, Dec. 5 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CLE 24 at CIN 20 | Final | CLE De'Andre Johnson 236 yds. | CLE Kelvin Diggs 57 yds. | CLE Alex Johnson 78 yds. |
| Week 14 | ||||
| Thu, Dec. 8 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SEA 27 at ATL 24 | Final | SEA Raymond Berry 237 yds. | SEA Bennett James 125 yds. | SEA Tyler Lockett 83 yds. |
| Sat, Dec. 10 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 20 at TEN 24 | Final | TEN Chance Wharden 266 yds. | TEN R.J. Cash 117 yds. | TEN James Roe 94 yds. |
| Sun, Dec. 11 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LV 17 at TB 14 | Final | LV Brendan Cyr 235 yds. | LV Ise Smith 166 yds. | LV Jamal Weekes 82 yds. |
| DAL 20 at PHI 41 | Final | PHI Sylvester James 361 yds. | PHI Paul Perkins 87 yds. | PHI Jaydon Thompson 189 yds. |
| BRO 17 at PIT 26 | Final | PIT Tommy Reese 274 yds. | PIT Madre London 136 yds. | PIT Madre London 71 yds. |
| ARI 23 at CLE 7 | Final | ARI Jon Fallon 221 yds. | ARI Otis Harper 77 yds. | ARI Kirby Moore 68 yds. |
| WAS 12 at DET 42 | Final | DET Brandon Peters 440 yds. | DET Gary Brightwell 93 yds. | DET Roy Roberts 228 yds. |
| STL 38 at CIN 26 | Final | STL Jayden Daniels 368 yds. | STL Jayden Daniels 73 yds. | STL Kennedy Lewis 118 yds. |
| NY 20 at CHI 21 | Final | NY Ryan Gable 216 yds. | NY Ryan Gable 31 yds. | NY Draymond Blackshear 85 yds. |
| IND 20 at MIL 13 | Final | IND Scott Tolzner 261 yds. | IND D.J. Oats 74 yds. | IND Dontario Drummond 93 yds. |
| BOS 20 at MIN 16 | Final | BOS Vance Becker 226 yds. | BOS Vance Becker 26 yds. | BOS Wesley Matthews 70 yds. |
| CAR 25 at NO 17 | Final | CAR John Locke 233 yds. | CAR John Locke 22 yds. | CAR Thomas Warner 49 yds. |
| CAL 34 at HOU 20 | Final | CAL Travis Wilson 346 yds. | CAL Micah Mason 187 yds. | CAL Courtney Smith 179 yds. |
| KC 34 at COL 28 | Final | KC Thaddeus Lewis 312 yds. | KC Jordan Morris 61 yds. | KC Andrew Pierce 114 yds. |
| BUF 31 at LA 28 | Final | BUF Kyle Allen 322 yds. | BUF Justin Jonas 115 yds. | BUF Marvin MacDonald 134 yds. |
| Mon, Dec. 12 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIA 17 at SD 27 | Final | SD Douglas Knotts 265 yds. | SD Earl Wregget 103 yds. | SD Kyi Wright 86 yds. |
| Week 15 | ||||
| Thu, Dec. 15 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BOS 17 at BAL 27 | Final | BAL Randy Carlysle 234 yds. | BAL Tim Harper 88 yds. | BAL Robert Gallo 76 yds. |
| Sat, Dec. 17 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CLE 16 at PHI 34 | Final | PHI Sylvester James 306 yds. | PHI Paul Perkins 70 yds. | PHI Jaydon Thompson 141 yds. |
| Sun, Dec. 18 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| WAS 13 at NY 17 | Final | NY Ryan Gable 222 yds. | NY Sherwood Brown 118 yds. | NY Draymond Blackshear 77 yds. |
| HOU 20 at MIA 24 | Final | MIA Adam Murray 236 yds. | MIA Darnell Sullivan 85 yds. | MIA Gary Jennings 71 yds. |
| KC 30 at CAR 24 | Final | KC Thaddeus Lewis 288 yds. | KC Jordan Morris 162 yds. | KC Kevin Kroger 83 yds. |
| NO 20 at ATL 17 | Final | NO Chris Coy 261 yds. | NO Austin Thomas 74 yds. | NO Jacob Mallory 79 yds. |
| CHI 17 at DET 30 | Final | DET Brandon Peters 329 yds. | DET Gary Brightwell 86 yds. | DET Jake Upton 173 yds. |
| BRO 17 at TEN 28 | Final | TEN Chance Wharden 214 yds. | TEN R.J. Cash 187 yds. | TEN R.J. Cash 66 yds. |
| MIL 24 at IND 23 | Final | MIL Richard Adams 287 yds. | MIL Kay'Ron Adams 73 yds. | MIL Matt Adams 81 yds. |
| CIN 28 at MIN 30 | Final | MIN Thomas Kaye 314 yds. | MIN Charles Hyder 115 yds. | MIN Domino Jenkins 127 yds. |
| TB 26 at STL 40 | Final | STL Jayden Daniels 361 yds. | STL Darren Holmes 74 yds. | STL Kennedy Lewis 156 yds. |
| COL 20 at DAL 17 | Final | COL Brandon Morris 242 yds. | COL Omni Wells 77 yds. | COL Jayson Lee 73 yds. |
| CAL 24 at LV 31 | Final | LV Brendan Cyr 286 yds. | LV Ise Smith 148 yds. | LV Jamal Weekes 112 yds. |
| ARI 20 at SEA 13 | Final | ARI Jon Fallon 216 yds. | ARI Otis Harper 118 yds. | ARI Kirby Moore 67 yds. |
| LA 21 at SD 29 | Final | SD Douglas Knotts 309 yds. | SD Earl Wregget 129 yds. | SD Mario Bates 117 yds. |
| Mon, Dec. 19 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PIT 28 at BUF 24 | Final | PIT Tommy Reese 280 yds. | PIT Madre London 162 yds. | PIT Marcus Floyd 74 yds. |
| Week 16 | ||||
| Thu, Dec. 22 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIA 28 at CLE 22 | Final | MIA Adam Murray 253 yds. | MIA Darnell Sullivan 81 yds. | MIA Devin Youngblood 82 yds. |
| Fri, Dec. 23 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 34 at BOS 23 | Final | DET Brandon Peters 371 yds. | DET Gary Brightwell 79 yds. | DET Jake Upton 140 yds. |
| Sat, Dec. 24 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| IND 27 at BRO 13 | Final | IND Scott Tolzner 277 yds. | IND D.J. Oats 123 yds. | IND Dontario Drummond 99 yds. |
| STL 27 at WAS 10 | Final | STL Jayden Daniels 245 yds. | STL Jayden Daniels 23 yds. | STL Kennedy Lewis 87 yds. |
| PIT 28 at BAL 24 | Final | PIT Tommy Reese 238 yds. | PIT Madre London 189 yds. | PIT Madre London 91 yds. |
| CAL 20 at CAR 34 | Final | CAR John Locke 214 yds. | CAR Thumba Hayes 167 yds. | CAR Austin Jones 84 yds. |
| NY 20 at ATL 23 | Final | ATL Ryan Glassman 224 yds. | ATL Chris L. Tucker 119 yds. | ATL Dominique Worthy 78 yds. |
| BUF 24 at CIN 23 | Final | BUF Kyle Allen 266 yds. | BUF Justin Jonas 74 yds. | BUF Marvin MacDonald 85 yds. |
| CHI 10 at COL 16 | Final | COL Brandon Morris 183 yds. | COL Omni Wells 61 yds. | COL Demarcus Robinson 58 yds. |
| HOU 30 at LV 26 | Final | HOU Bill Hastings 229 yds. | HOU Milo Hall 120 yds. | HOU Jordan Higgins 72 yds. |
| MIN 24 at ARI 20 | Final | MIN Thomas Kaye 255 yds. | MIN Charles Hyder 128 yds. | MIN Domino Jenkins 83 yds. |
| SD 23 at TB 31 | Final | TB Calvin Ayre 306 yds. | TB Cedric Miles 114 yds. | TB Otis Glendale 131 yds. |
| Sun, Dec. 25 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PHI 30 at NO 33 | Final | NO Chris Coy 329 yds. | NO Austin Thomas 136 yds. | NO Jacob Mallory 144 yds. |
| DAL 40 at SEA 6 | Final | DAL Adam Froman 376 yds. | DAL Jevon Jones 157 yds. | DAL Antonio Tucker 186 yds. |
| KC 23 at LA 13 | Final | KC Thaddeus Lewis 236 yds. | KC Jordan Morris 128 yds. | KC Kevin Kroger 92 yds. |
| Mon, Dec. 26 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIL 33 at TEN 24 | Final | MIL Richard Adams 315 yds. | MIL Kay'Ron Adams 144 yds. | MIL Greg Chatham 125 yds. |
| Week 17 | ||||
| Thu, Dec. 29 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 10 at DET 42 | Final | DET Brandon Peters 410 yds. | DET Gary Brightwell 114 yds. | DET Roy Roberts 187 yds. |
| Sat, Dec. 31 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIN 10 at NY 34 | Final | NY Ryan Gable 338 yds. | NY Sherwood Brown 108 yds. | NY Draymond Blackshear 147 yds. |
| CIN 24 at BRO 3 | Final | CIN Kevin Hogan 239 yds. | CIN Kenyon Barnes 118 yds. | CIN J.J. Jefferson 92 yds. |
| SEA 20 at WAS 13 | Final | SEA Raymond Berry 216 yds. | SEA Bennett James 77 yds. | SEA Anthony Jones 67 yds. |
| IND 3 at CLE 24 | Final | CLE De'Andre Johnson 261 yds. | CLE Kelvin Diggs 89 yds. | CLE Pharoah Brown 86 yds. |
| ATL 20 at CHI 19 | Final | ATL Ryan Glassman 192 yds. | ATL Chris L. Tucker 53 yds. | ATL Dominique Worthy 48 yds. |
| ARI 9 at STL 34 | Final | STL Jayden Daniels 318 yds. | STL Jayden Daniels 33 yds. | STL Kennedy Lewis 118 yds. |
| CAR 24 at KC 28 | Final | KC Thaddeus Lewis 281 yds. | KC Jordan Morris 97 yds. | KC Andrew Pierce 104 yds. |
| LA 12 at HOU 17 | Final | HOU Bill Hastings 186 yds. | HOU Milo Hall 77 yds. | HOU Milo Hall 61 yds. |
| MIA 20 at COL 24 | Final | COL Brandon Morris 216 yds. | COL Omni Wells 80 yds. | COL Jayson Lee 65 yds. |
| LV 29 at CAL 31 | Final | CAL Travis Wilson 336 yds. | CAL Micah Mason 141 yds. | CAL David Wesley 150 yds. |
| TEN 13 at BUF 30 | Final | BUF Kyle Allen 304 yds. | BUF Justin Jonas 107 yds. | BUF Marvin MacDonald 129 yds. |
| Sun, Jan. 1 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PHI 20 at PIT 26 | Final | PIT Tommy Reese 261 yds. | PIT Madre London 128 yds. | PIT Madre London 76 yds. |
| NO 20 at SD 28 | Final | SD Douglas Knotts 265 yds. | SD Earl Wregget 119 yds. | SD Kyi Wright 70 yds. |
| TB 6 at DAL 41 | Final | DAL Adam Froman 349 yds. | DAL Jevon Jones 112 yds. | DAL Antonio Tucker 151 yds. |
| Mon, Jan. 2 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BOS 28 at MIL 44 | Final | MIL Richard Adams 427 yds. | MIL Kay'Ron Adams | MIL Greg Chatham 188 yds. |
| Week 18 | ||||
| Thu, Jan. 5 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| KC 34 at NO 10 | Final | KC Thaddeus Lewis 338 yds. | KC Jordan Morris 124 yds. | KC J.J. Reed 155 yds. |
| Fri, Jan. 6 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DAL 22 at ARI 18 | Final | DAL Adam Froman 229 yds. | DAL Jevon Jones 70 yds. | DAL Antonio Tucker 56 yds. |
| Sat, Jan. 7 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 24 at BRO 6 | Final | BAL Randy Carlysle 236 yds. | BAL Tim Harper 68 yds. | BAL Charles Hunt 72 yds. |
| MIN 28 at CIN 17 | Final | MIN Thomas Kaye 263 yds. | MIN Charles Hyder 132 yds. | MIN Domino Jenkins 77 yds. |
| TEN 20 at BOS 21 | Final | BOS Vance Becker 223 yds. | BOS Wesley Matthews 27 yds. | BOS Brian Lee 80 yds. |
| DET 36 at MIL 37 | Final | MIL Richard Adams 319 yds. | MIL Kay'Ron Adams 78 yds. | MIL Matt Adams 130 yds. |
| Sun, Jan. 8 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| STL 24 at MIA 26 | Final | MIA Adam Murray 261 yds. | MIA Darnell Sullivan 108 yds. | MIA Devin Youngblood 87 yds. |
| NY 6 at PHI 24 | Final | PHI Sylvester James 226 yds. | PHI Paul Perkins 58 yds. | PHI Jaydon Thompson 73 yds. |
| BUF 28 at PIT 27 | Final | BUF Kyle Allen 270 yds. | BUF Justin Jonas 91 yds. | BUF Marvin MacDonald 97 yds. |
| WAS 28 at CLE 0 | Final | WAS Austin McNiel 276 yds. | WAS Justice Hill 118 yds. | WAS Geno Lewis 109 yds. |
| CAR 20 at ATL 24 | Final | ATL Ryan Glassman 242 yds. | ATL Chris L. Tucker 87 yds. | ATL Dominique Worthy 84 yds. |
| CHI 8 at IND 20 | Final | IND Scott Tolzner 221 yds. | IND D.J. Oats 68 yds. | IND Dontario Drummond 78 yds. |
| TB 24 at HOU 23 | Final | TB Calvin Ayre 199 yds. | TB Cedric Miles 55 yds. | TB Otis Glendale 67 yds. |
| COL 26 at SEA 23 | Final | COL Brandon Morris 234 yds. | COL Omni Wells 49 yds. | COL Demarcus Robinson 66 yds. |
| SD 17 at LV 28 | Final | LV Brendan Cyr 236 yds. | LV Ise Smith 144 yds. | LV Edward Canterbury 89 yds. |
| CAL 39 at LA 13 | Final | CAL Travis Wilson 364 yds. | CAL Micah Mason 152 yds. | CAL Courtney Smith 173 yds. |
| 2022 AFL POST SEASON SCHEDULE |
||||
| Wild Card Round | ||||
| Sat, Jan. 14 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TB 23 at MIA 41 | Final | MIA Adam Murray 332 yds. | MIA Darnell Sullivan 119 yds. | TB Otis Glendale 136 yds. |
| SEA 30 at DAL 31 | Final | DAL Adam Froman 288 yds. | DAL Jevon Jones 109 yds. | SEA Jevon Jones 109 yds. |
| Sun, Jan. 15 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIN 31 at BAL 34 | Final | BAL Randy Carlysle 352 yds. | BAL Tim Harper 48 yds. | BAL Charles Hunt 114 yds. |
| NY 31 at PHI 24 | Final | NY Ryan Gable 301 yds. | NY Sherwood Brown 78 yds. | PHI Henry Krieger 129 yds. |
| ARI 17 at DET 24 | Final | ARI Jon Fallon 226 yds. | ARI Otis Harper 62 yds. | DET Roy Roberts 84 yds. |
| Mon, Jan. 16 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| STL 31 at CAL 14 | Final | CAL Travis Wilson 351 yds. | STL Kennedy Lewis 77 yds. | STL Kennedy Lewis 95 yds. |
| Divisional Round | ||||
| Sat, Jan. 21 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 20 at MIA 27 | Final | BAL Randy Carlysle 217 yds. | MIA Darnell Sullivan 95 yds. | MIA Devin Youngblood 98 yds. |
| NY 7 at KC 38 | Final | KC Thaddeus Lewis 154 yds. | KC Jordan Morris 112 yds. | KC Kevin Kroger 61 yds. |
| Sun, Jan. 22 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| STL 27 at BUF 10 | Final | BUF Kyle Allen 265 yds. | STL Jayden Daniels 105 yds. | BUF Nick Hill 65 yds. |
| DAL 12 at DET 19 | Final | DET Brandon Peters 214 yds. | DET Gary Brightwell 51 yds. | DAL Antonio Tucker 117 yds. |
| Conference Championships | ||||
| Sun, Jan. 29 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| STL 7 at MIA 31 | Final | MIA Adam Murray 121 yds. | STL Jayden Daniels 84 yds. | MIA Devin Youngblood 36 yds. |
| DET 20 at KC 23 | Final | KC Thaddeus Lewis 326 yds. | DET Gary Brightwell 30 yds. | KC J.J. Reed 116 yds. |
| Super Bowl XXXIX | ||||
| Sun, Feb. 5 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIA 17 at KC 45 | Final | KC Thaddeus Lewis 412 yds. | KC Jordan Morris 154 yds. | KC Andrew Pierce 146 yds. |