| Week 1 | ||||
| Thu, Sep. 9 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 31 at CHI 22 | Final | DET Brandon Peters 342 yds. | DET Gary Brightwell 117 yds. | DET Taiwan Jones 122 yds. |
| Sat, Sep. 11 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PIT 24 at TEN 30 | Final | TEN Chance Wharden 319 yds. | TEN R.J. Cash 126 yds. | TEN James Roe 144 yds. |
| Sun, Sep. 12 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NY 21 at BUF 20 | Final | NY Scott Tolzner 236 yds. | NY Sherwood Brown 108 yds. | NY Draymond Blackshear 110 yds. |
| HOU 27 at CAR 19 | Final | HOU De'Andre Johnson 194 yds. | HOU Milo Hall 77 yds. | HOU Jordan Higgins 63 yds. |
| BRO 14 at PHI 28 | Final | PHI Sylvester James 287 yds. | PHI Delious Childs 92 yds. | PHI Cookie Wallace 91 yds. |
| BOS 26 at CLE 17 | Final | BOS Vance Becker 231 yds. | BOS Howard Jenkins 50 yds. | BOS Howard Jenkins 89 yds. |
| MIA 30 at ATL 13 | Final | MIA Adam Murray 226 yds. | MIA Darnell Sullivan 110 yds. | MIA Devin Youngblood 103 yds. |
| CIN 27 at MIL 3 | Final | CIN Kevin Hogan 314 yds. | CIN Tre Ellis 49 yds. | CIN Tre Ellis 121 yds. |
| WAS 18 at MIN 17 | Final | WAS Andrew Miller 184 yds. | WAS Justice Hill 87 yds. | WAS Jayar Jackson 93 yds. |
| DAL 20 at STL 22 | Final | STL Kyle Allen 211 yds. | STL Kyle Allen 36 yds. | STL Kennedy Lewis 70 yds. |
| IND 14 at COL 28 | Final | COL Hector Knoles 216 yds. | COL Omni Wells 53 yds. | COL Omni Wells 78 yds. |
| NO 38 at LA 27 | Final | NO Chris Coy 327 yds. | NO Austin Thomas 142 yds. | NO Jacob Mallory 118 yds. |
| LV 24 at CAL 41 | Final | CAL Travis Wilson 323 yds. | CAL Micah Mason 133 yds. | CAL Courtney Smith 129 yds. |
| SEA 34 at KC 33 | Final | SEA Brandon Morris 339 yds. | SEA Bennett James 106 yds. | SEA Demarcus Robinson 125 yds. |
| Mon, Sep. 13 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 17 at TB 31 | Final | TB Calvin Ayre 319 yds. | TB Cedric Miles 64 yds. | TB Otis Glendale 153 yds. |
| SD 46 at ARI 23 | Final | SD Douglas Knotts 419 yds. | SD Earl Wregget 133 yds. | SD Wallace Poole 177 yds. |
| Week 2 | ||||
| Thu, Sep. 16 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LA 41 at BUF 23 | Final | LA Rayce Dawson 376 yds. | LA Rashard Jackson 122 yds. | LA Taiwan Jones 143 yds. |
| Sun, Sep. 19 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIL 31 at NY 17 | Final | MIL Richard Adams 362 yds. | MIL Kay'Ron Adams 137 yds. | MIL Greg Chatham 179 yds. |
| KC 24 at WAS 26 | Final | WAS Andrew Miller 244 yds. | WAS Justice Hill 121 yds. | WAS Jayar Jackson 117 yds. |
| BOS 17 at BAL 27 | Final | BAL Randy Carlysle 265 yds. | BAL Tim Harper 77 yds. | BAL Charles Hunt 103 yds. |
| BRO 6 at TB 48 | Final | TB Calvin Ayre 456 yds. | TB Cedric Miles 111 yds. | TB Jailyn Marshall 231 yds. |
| ATL 9 at PHI 20 | Final | PHI Sylvester James 226 yds. | PHI Delious Childs 65 yds. | PHI Cookie Wallace 79 yds. |
| CIN 24 at PIT 23 | Final | CIN Kevin Hogan 287 yds. | CIN Tre Ellis 44 yds. | CIN Tre Ellis 76 yds. |
| IND 24 at DET 27 | Final | DET Brandon Peters 331 yds. | DET Gary Brightwell 83 yds. | DET Patrick Allen 90 yds. |
| CAR 34 at CHI 11 | Final | CAR Dale Gooden 272 yds. | CAR Paul Perkins 77 yds. | CAR Paul Perkins 88 yds. |
| MIA 30 at NO 3 | Final | MIA Adam Murray 266 yds. | MIA Darnell Sullivan 71 yds. | MIA Gary Jennings 92 yds. |
| HOU 21 at MIN 20 | Final | HOU De'Andre Johnson 232 yds. | HOU Milo Hall 66 yds. | HOU Jordan Higgins 58 yds. |
| SD 34 at STL 17 | Final | SD Douglas Knotts 316 yds. | SD Earl Wregget 122 yds. | SD Wallace Poole 127 yds. |
| CAL 17 at COL 24 | Final | COL Hector Knoles 221 yds. | COL Omni Wells 110 yds. | COL Walt Jacobs 68 yds. |
| DAL 24 at ARI 28 | Final | ARI Jon Fallon 320 yds. | ARI Otis Harper 142 yds. | ARI Marvin MacDonald 83 yds. |
| TEN 30 at CLE 28 | Final | TEN Chance Wharden 314 yds. | TEN R.J. Cash 135 yds. | TEN Josiah Price 136 yds. |
| Mon, Sep. 20 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LV 28 at SEA 27 | Final | LV Brett Smith 228 yds. | LV Ise Smith 197 yds. | LV Jamal Weekes 87 yds. |
| Week 3 | ||||
| Thu, Sep. 23 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ARI 37 at MIL 31 | Final | ARI Jon Fallon 359 yds. | ARI Otis Harper 126 yds. | ARI Marvin MacDonald 174 yds. |
| Sun, Sep. 26 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIA 18 at BRO 6 | Final | MIA Adam Murray 222 yds. | MIA Darnell Sullivan 72 yds. | MIA Gary Jennings 63 yds. |
| HOU 20 at BOS 15 | Final | HOU De'Andre Johnson 229 yds. | HOU Milo Hall 66 yds. | HOU Milo Hall 81 yds. |
| STL 20 at BAL 22 | Final | BAL Randy Carlysle 248 yds. | BAL Randy Carlysle 111 yds. | BAL Charles Hunt 113 yds. |
| NY 9 at CAR 27 | Final | CAR Dale Gooden 273 yds. | CAR Paul Perkins 118 yds. | CAR Koffer Austin 96 yds. |
| CLE 17 at ATL 27 | Final | ATL Ryan Glassman 296 yds. | ATL Chris L. Tucker 121 yds. | ATL Mike Martinez 117 yds. |
| COL 18 at DET 16 | Final | COL Hector Knoles 210 yds. | COL Omni Wells 73 yds. | COL Cooper Jackson 81 yds. |
| DAL 38 at IND 4 | Final | DAL Adam Froman 386 yds. | DAL Jevon Jones 143 yds. | DAL Antonio Tucker 214 yds. |
| WAS 20 at NO 37 | Final | NO Chris Coy 347 yds. | NO Austin Thomas 80 yds. | NO Jayson Lee 120 yds. |
| PHI 27 at KC 24 | Final | PHI Sylvester James 231 yds. | PHI Delious Childs 68 yds. | PHI Cookie Wallace 77 yds. |
| CIN 20 at LV 29 | Final | LV Brett Smith 269 yds. | LV Ise Smith 124 yds. | LV Edward Canterbury 108 yds. |
| PIT 13 at LA 44 | Final | LA Rayce Dawson 429 yds. | LA Rashard Jackson 104 yds. | LA Taiwan Jones 163 yds. |
| BUF 30 at CAL 21 | Final | BUF Travis Colin 272 yds. | BUF Justin Jonas 58 yds. | BUF Marcus Floyd 119 yds. |
| MIN 28 at SD 41 | Final | SD Douglas Knotts 408 yds. | SD Earl Wregget 135 yds. | SD Wallace Poole 179 yds. |
| SEA 20 at CHI 10 | Final | SEA Brandon Morris 247 yds. | SEA Bennett James 93 yds. | SEA Demarcus Robinson 89 yds. |
| Mon, Sep. 27 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TB 28 at TEN 30 | Final | TEN Chance Wharden 264 yds. | TEN R.J. Cash 141 yds. | TEN Josiah Price 88 yds. |
| Week 4 | ||||
| Thu, Sep. 30 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| KC 38 at LV 27 | Final | KC Thaddeus Lewis 340 yds. | KC Jordan Morris 118 yds. | KC Kevin Kroger 139 yds. |
| Sun, Oct. 3 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 28 at NY 27 | Final | BAL Randy Carlysle 252 yds. | BAL Tim Harper 122 yds. | BAL Charles Hunt 79 yds. |
| WAS 24 at PHI 20 | Final | WAS Andrew Miller 218 yds. | WAS Justice Hill 63 yds. | WAS Marcus Kemp 71 yds. |
| ATL 23 at CAR 14 | Final | ATL Ryan Glassman 247 yds. | ATL Chris L. Tucker 63 yds. | ATL Dominique Worthy 81 yds. |
| BUF 40 at CIN 7 | Final | BUF Travis Colin 433 yds. | BUF Justin Jonas 166 yds. | BUF Marcus Floyd 200 yds. |
| ARI 34 at IND 24 | Final | ARI Jon Fallon 419 yds. | ARI Otis Harper 126 yds. | ARI Marvin MacDonald 183 yds. |
| CAL 21 at MIN 15 | Final | CAL Travis Wilson 209 yds. | CAL Micah Mason 149 yds. | CAL Courtney Smith 80 yds. |
| LA 20 at DAL 41 | Final | DAL Adam Froman 413 yds. | DAL Jevon Jones 152 yds. | DAL Antonio Tucker 156 yds. |
| BRO 21 at HOU 20 | Final | BRO Matt Johnson 224 yds. | BRO Kenyon Barnes 128 yds. | BRO Tyler Lockett 87 yds. |
| CLE 40 at NO 21 | Final | CLE John Locke 443 yds. | CLE Kelvin Diggs 107 yds. | CLE Pharoah Brown 223 yds. |
| Mon, Oct. 4 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TEN 28 at BOS 17 | Final | TEN Chance Wharden 214 yds. | TEN R.J. Cash 133 yds. | TEN Josiah Price 88 yds. |
| Week 5 | ||||
| Thu, Oct. 7 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SEA 20 at LA 37 | Final | LA Rayce Dawson 389 yds. | LA Rashard Jackson 132 yds. | LA Taiwan Jones 147 yds. |
| Sun, Oct. 10 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| STL 17 at BRO 20 | Final (ot) | BRO Matt Johnson 193 yds. | BRO Kenyon Barnes 107 yds. | BRO Tyler Lockett 114 yds. |
| BOS 27 at WAS 24 | Final (ot) | BOS Vance Becker 233 yds. | BOS Vance Becker 41 yds. | BOS Howard Jenkins 87 yds. |
| MIA 20 at BUF 31 | Final | BUF Travis Colin 308 yds. | BUF Justin Jonas 127 yds. | BUF Marcus Floyd 149 yds. |
| BAL 28 at PHI 14 | Final | BAL Randy Carlysle 317 yds. | BAL Tim Harper 105 yds. | BAL Charles Hunt 116 yds. |
| COL 10 at CHI 34 | Final | CHI Ryan Gable 353 yds. | CHI Duane Banks 109 yds. | CHI B.J. MacIntyre 172 yds. |
| HOU 10 at TEN 41 | Final | TEN Chance Wharden 398 yds. | TEN R.J. Cash 156 yds. | TEN Josiah Price 212 yds. |
| DET 17 at ARI 38 | Final | ARI Jon Fallon 364 yds. | ARI Otis Harper 108 yds. | ARI Marvin MacDonald 126 yds. |
| PIT 31 at SD 27 | Final (ot) | PIT Tommy Reese 320 yds. | PIT Jay Dillon 87 yds. | PIT Nick Hill 78 yds. |
| TB 37 at KC 29 | Final | TB Calvin Ayre 414 yds. | TB Cedric Miles 111 yds. | TB Otis Glendale 163 yds. |
| Mon, Oct. 11 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NO 14 at MIL 34 | Final | MIL Richard Adams 371 yds. | MIL Kay'Ron Adams 133 yds. | MIL Greg Chatham 157 ydsd. |
| Week 6 | ||||
| Thu, Oct. 14 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DAL 40 at LV 27 | Final | DAL Adam Froman 429 yds. | DAL Jevon Jones 163 yds. | DAL Antonio Tucker 221 yds. |
| Sun, Oct. 17 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NY 20 at CLE 34 | Final | CLE John Locke 348 yds. | CLE Kelvin Diggs 99 yds. | CLE Alex Johnson 145 yds. |
| CAR 24 at ATL 20 | Final | CAR Dale Gooden 215 yds. | CAR Paul Perkins 145 yds. | CAR Paul Perkins 77 yds. |
| SEA 18 at DET 30 | Final | DET Brandon Peters 322 yds. | DET Gary Brightwell 121 yds. | DET Patrick Allen 104 yds. |
| IND 28 at MIN 17 | Final | IND Austin McNiel 313 yds. | IND Andre Duncan 104 yds. | IND Roy Roberts 94 yds. |
| MIA 20 at STL 21 | Final | STL Kyle Allen 217 yds. | STL Kyle Allen 81 yds. | STL Kennedy Lewis 73 yds. |
| CIN 34 at CAL 14 | Final | CIN Kevin Hogan 351 yds. | CIN Kenyon Barnes 129 yds. | CIN J.J. Jefferson 173 yds. |
| COL 10 at SD 38 | Final | SD Douglas Knotts 366 yds. | SD Earl Wregget 118 yds. | SD Mario Bates 187 yds. |
| MIL 28 at CHI 27 | Final | MIL Richard Adams 338 yds. | MIL Kay'Ron Adams 142 yds. | MIL Matt Adams 176 yds. |
| Mon, Oct. 18 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TB 28 at PIT 23 | Final | TB Calvin Ayre 326 yds. | TB Cedric Miles 118 yds. | Adam Karlosky 140 yds. |
| Week 7 | ||||
| Thu, Oct. 21 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TEN 38 at MIA 27 | Final | TEN Chance Wharden 274 yds. | TEN R.J. Cash 133 yds. | TEN James Roe 89 yds. |
| Sun, Oct. 24 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| IND 31 at BRO 10 | Final | IND Austin McNiel 276 yds. | IND Andre Duncan 118 yds. | IND Roy Roberts 103 yds. |
| SD 34 at BUF 17 | Final | SD Douglas Knotts 318 yds. | SD Earl Wregget 124 yds. | SD Mario Bates 117 yds. |
| WAS 10 at BAL 38 | Final | BAL Randy Carlysle 262 yds. | BAL Tim Harper 77 yds. | BAL Marshall Hall 94 yds. |
| PHI 28 at CAR 6 | Final | PHI Sylvester James 260 yds. | PHI Delious Childs 83 yds. | PHI Cookie Wallace 77 yds. |
| CAL 28 at PIT 30 | Final | PIT Tommy Reese 251 yds. | PIT Jay Dillon 101 yds. | PIT Jason Avenhill 79 yds. |
| LA 33 at CIN 31 | Final | LA Rayce Dawson 363 yds. | LA Rashard Jackson 104 yds. | LA Jayar Jackson 98 yds. |
| MIN 28 at CHI 27 | Final | MIN Thomas Kaye 249 yds. | MIN Charles Hyder 175 yds. | MIN Domino Jenkins 83 yds. |
| BOS 54 at STL 7 | Final | BOS Vance Becker 469 yds. | BOS Wesley Matthews 48 yds. | BOS Wesley Matthews 212 yds. |
| DET 34 at DAL 18 | Final | DET Brandon Peters 287 yds. | DET Gary Brightwell 124 yds. | DET Patrick Allen 118 yds. |
| ATL 24 at HOU 21 | Final | ATL Ryan Glassman 261 yds. | ATL Chris L. Tucker 78 yds. | ATL Mike Martinez 102 yds. |
| NY 27 at ARI 34 | Final | ARI Jon Fallon 329 yds. | ARI Otis Harper 118 yds. | ARI Kirby Moore 111 yds. |
| COL 15 at LV 28 | Final | LV Brett Smith 226 yds. | LV Ise Smith 166 yds. | LV Jamal Weekes 63 yds. |
| MIL 34 at SEA 27 | Final | MIL Richard Adams 334 yds. | MIL Kay'Ron Adams 107 yds. | MIL Dabney Myron 118 yds. |
| KC 6 at CLE 31 | Final | CLE John Locke 362 yds. | CLE Kelvin Diggs 69 yds. | CLE Theo Howard 124 yds. |
| Mon, Oct. 25 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NO 38 at TB 27 | Final | NO Chris Coy 338 yds. | NO Austin Thomas 125 yds. | NO Jayson Lee 127 yds. |
| Week 8 | ||||
| Thu, Oct. 28 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CHI 24 at BUF 27 | Final | BUF Travis Colin 262 yds/ | BUF Justin Jonas 103 yds. | BUF Marcus Floyd 81 yds. |
| Sun, Oct. 31 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TB 28 at BOS 44 | Final | BOS Vance Becker 356 yds. | BOS Vance Becker 81 yds. | BOS Wesley Matthews 127 yds. |
| BRO 24 at NY 28 | Final | NY Scott Tolzner 287 yds. | NY Sherwood Brown 123 yds. | NY Deagen Motts 107 yds. |
| MIA 18 at BAL 23 | Final | BAL Randy Carlysle 243 yds. | BAL Tim Harper 109 yds. | BAL Charles Hunt 77 yds. |
| MIN 20 at PIT 26 | Final | PIT Tommy Reese 229 yds. | PIT Jay Dillon 133 yds. | PIT Nick Hill 85 yds. |
| CAR 28 at CLE 26 | Final | CAR Dale Gooden 238 yds. | CAR Paul Perkins 92 yds. | CAR Paul Perkins 81 yds. |
| WAS 21 at ATL 20 | Final | WAS Andrew Miller 183 yds. | WAS Justice Hill 59 yds. | WAS Marcus Kemp 62 yds. |
| DET 38 at CIN 27 | Final | DET Brandon Peters 266 yds. | DET Gary Brightwell 181 yds. | DET Patrick Allen 104 yds. |
| PHI 20 at TEN 27 | Final | TEN Chance Wharden 296 yds. | TEN R.J. Cash 150 yds. | TEN Josiah Price 70 yds. |
| IND 27 at MIL 33 | Final | MIL Richard Adams 328 yds. | MIL Kay'Ron Adams 114 yds. | MIL Greg Chatham 124 yds. |
| STL 23 at HOU 18 | Final | STL Kyle Allen 229 yds. | HOU Milo Hall 120 yds. | STL Kennedy Lewis 77 yds. |
| ARI 20 at LV 31 | Final | LV Brett Smith 262 yds. | LV Ise Smith 153 yds. | LV Jamal Weekes 81 yds. |
| COL 8 at SEA 34 | Final | SEA Brandon Morris 256 yds. | SEA Bennett James 83 yds. | SEA Anthony Jones 117 yds. |
| DAL 30 at CAL 29 | Final | DAL Adam Froman 277 yds. | DAL Jevon Jones 88 yds. | DAL Antonio Tucker 101 yds. |
| SD 20 at LA 37 | Final | LA Rayce Dawson 375 yds. | LA Rashard Jackson 136 yds. | LA Jai Williams 167 yds. |
| Mon, Nov. 1 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| KC 28 at NO 30 | Final | NO Chris Coy 297 yds. | NO Austin Thomas 115 yds. | NO Jacob Mallory 106 yds. |
| Week 9 | ||||
| Thu, Nov. 4 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ARI 33 at MIA 17 | Final | ARI Jon Fallon 328 yds. | ARI Otis Harper 119 yds. | ARI Marvin MacDonald 157 yds. |
| Sun, Nov. 7 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CHI 28 at WAS 27 | Final | CHI Ryan Gable 263 yds. | CHI Duane Banks 118 yds. | CHI B.J. MacIntyre 110 yds. |
| COL 29 at CAR 24 | Final | COL Hector Knoles 186 yds. | COL Omni Wells 92 yds. | COL Omni Wells 67 yds. |
| NO 20 at PHI 27 | Final | PHI Sylvester James 221 yds. | PHI Delious Childs 77 yds. | PHI Cookie Wallace 86 yds. |
| HOU 20 at TB 33 | Final | TB Calvin Ayre 339 yds. | TB Cedric Miles 76 yds. | TB Otis Glendale 115 yds. |
| PIT 21 at DET 27 | Final | DET Brandon Peters 242 yds. | DET Gary Brightwell 162 yds. | DET Patrick Allen 73 yds. |
| ATL 28 at IND 17 | Final | ATL Ryan Glassman 233 yds. | ATL Chris L. Tucker 117 yds. | ATL Mike Martinez 99 yds. |
| DAL 28 at MIL 13 | Final | DAL Adam Froman 266 yds. | DAL Jevon Jones 124 yds. | DAL Antonio Tucker 106 yds. |
| CIN 17 at MIN 26 | Final | MIN Thomas Kaye 264 yds. | MIN Charles Hyder 114 yds. | MIN Kendall Price 96 yds. |
| TEN 20 at STL 21 | Final | STL Kyle Allen 218 yds. | STL Kyle Allen 101 yds. | STL Kennedy Lewis 70 yds. |
| NY 20 at KC 31 | Final | KC Thaddeus Lewis 346 yds. | KC Jordan Morris 149 yds. | KC J.J. Reed 118 yds. |
| BUF 20 at LV 16 | Final | BUF Travis Colin 228 yds. | BUF Justin Jonas 107 yds. | BUF Marcus Floyd 67 yds. |
| BAL 28 at LA 13 | Final | BAL Randy Carlysle 254 yds. | BAL Tim Harper 87 yds. | BAL Charles Hunt 96 yds. |
| BRO 18 at SD 36 | Final | SD Douglas Knotts 366 yds. | SD Earl Wregget 108 yds. | SD Daryll Kincaid 126 yds. |
| CLE 44 at SEA 17 | Final | CLE John Locke 408 yds. | CLE Kelvin Diggs 66 yds. | CLE Alex Johnson 217 yds. |
| Mon, Nov. 8 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BOS 24 at CAL 20 | Final | BOS Vance Becker 231 yds. | BOS Wesley Matthews 58 yds. | BOS Wesley Matthews 88 yds. |
| Week 10 | ||||
| Thu, Nov. 11 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 28 at TEN 31 | Final | TEN Chance Wharden 314 yds. | TEN R.J. Cash 153 yds. | TEN Josiah Price 129 yds. |
| Sun, Nov. 14 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BRO 8 at BOS 33 | Final | BOS Vance Becker 374 yds. | BOS Vance Becker 38 yds. | BOS Brian Lee 172 yds. |
| CLE 20 at WAS 18 | Final | CLE John Locke 223 yds. | CLE Kelvin Diggs 57 yds. | CLE Theo Howard 103 yds. |
| PHI 30 at NY 17 | Final | PHI Sylvester James 313 yds. | PHI Sylvester James 72 yds. | PHI Cookie Wallace 104 yds. |
| CIN 20 at BUF 31 | Final | BUF Travis Colin 283 yds. | BUF Justin Jonas 165 yds. | BUF Marcus Floyd 81 yds. |
| MIA 29 at TB 27 | Final | MIA Adam Murray 277 yds. | MIA Darnell Sullivan 84 yds. | MIA Devin Youngblood 117 yds. |
| CHI 23 at DET 38 | Final | DET Brandon Peters 334 yds. | DET Gary Brightwell 136 yds. | DET Patrick Allen 111 yds. |
| MIL 37 at IND 31 | Final | MIL Richard Adams 349 yds. | MIL Kay'Ron Adams 126 yds. | MIL Greg Chatham 151 yds. |
| PIT 17 at MIN 31 | Final | MIN Thomas Kaye 252 yds. | MIN Charles Hyder 112 yds. | MIN Domino Jenkins 86 yds. |
| ATL 27 at NO 20 | Final | ATL Ryan Glassman 280 yds. | ATL Chris L. Tucker 113 yds. | ATL Mike Martinez 127 yds. |
| HOU 22 at STL 20 | Final | HOU De'Andre Johnson 196 yds. | HOU Milo Hall 55 yds. | HOU Milo Hall 68 yds. |
| CAR 6 at KC 30 | Final | KC Thaddeus Lewis 338 yds. | KC Jordan Morris 120 yds. | KC Kevin Kroger 132 yds. |
| DAL 41 at COL 23 | Final | DAL Adam Froman 414 yds. | DAL Jevon Jones 178 yds. | DAL Arik Gilbert 203 yds. |
| CAL 28 at LA 23 | Final | CAL Travis Wilson 248 yds. | CAL Micah Mason 165 yds. | CAL Courtney Smith 93 yds. |
| SD 36 at LV 28 | Final | SD Douglas Knotts 369 yds. | SD Earl Wregget 126 yds. | SD Mario Bates 118 yds. |
| Mon, Nov. 15 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SEA 6 at ARI 27 | Final | ARI Jon Fallon 279 yds. | ARI Otis Harper 108 yds. | ARI Marvin MacDonald 117 yds. |
| Week 11 | ||||
| Thu, Nov. 18 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| KC 29 at MIA 30 | Final | MIA Adam Murray 278 yds. | MIA Darnell Sullivan 135 yds. | MIA Devin Youngblood 89 yds. |
| Sun, Nov. 21 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CLE 20 at BAL 17 | Final | CLE John Locke 220 yds. | CLE Kelvin Diggs 61 yds. | CLE Alex Johnson 82 yds. |
| WAS 24 at BRO 13 | Final | WAS Andrew Miller 262 yds. | WAS Justice Hill 66 yds. | WAS Justice Hill 84 yds. |
| PHI 20 at BOS 41 | Final | BOS Vance Becker 397 yds. | BOS Vance Becker 38 yds. | BOS Wesley Matthews 177 yds. |
| STL 13 at ATL 17 | Final | ATL Ryan Glassman 239 yds. | ATL Chris L. Tucker 76 yds. | ATL Mike Martinez 80 yds. |
| MIN 31 at DET 30 | Final | MIN Thomas Kaye 326 yds. | MIN Charles Hyder 133 yds. | MIN Domino Jenkins 119 yds. |
| CIN 27 at IND 48 | Final | IND Austin McNiel 432 yds. | IND Andre Duncan 126 yds. | IND Roy Roberts 230 yds. |
| NY 28 at TEN 17 | Final | NY Scott Tolzner 276 yds. | NY Sherwood Brown 118 yds. | NY Draymond Blackshear 107 yds. |
| PIT 30 at CHI 20 | Final | PIT Tommy Reese 314 yds. | PIT Jay Dillon 97 yds. | PIT Nick Hill 132 yds. |
| SEA 13 at DAL 38 | Final | DAL Adam Froman 374 yds. | DAL Jevon Jones 126 yds. | DAL Leonardo Hughes 157 yds. |
| NO 24 at HOU 10 | Final | NO Chris Coy 241 yds. | NO Austin Thomas 77 yds. | NO Jayson Lee 93 yds. |
| ARI 41 at COL 10 | Final | ARI Jon Fallon 340 yds. | ARI Otis Harper 128 yds. | ARI Marvin MacDonald 146 yds. |
| CAR 20 at CAL 33 | Final | CAL Travis Wilson 317 yds. | CAL Micah Mason 166 yds. | CAL Chester Purtan 123 yds. |
| LA 20 at SD 33 | Final | SD Douglas Knotts 339 yds. | SD Earl Wregget 132 yds. | SD Wallace Poole 173 yds. |
| BUF 41 at MIL 40 | Final | BUF Travis Colin 390 yds. | BUF Justin Jonas 146 yds. | BUF Miles Dixon 135 yds. |
| Mon, Nov. 22 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LV 17 at TB 28 | Final | TB Calvin Ayre 311 yds. | TB Cedric Miles 74 yds. | TB Otis Glendale 108 yds. |
| Week 12 | ||||
| Thu, Nov. 25 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIL 37 at DET 43 | Final (ot) | DET Brandon Peters 457 yds. | DET Gary Brightwell 223 yds. | DET Patrick Allen 179 yds. |
| SD 37 at DAL 34 | Final (ot) | SD Douglas Knotts 323 yds. | SD Earl Wregget 118 yds. | SD Mario Bates 114 yds. |
| CLE 20 at PIT 31 | Final | PIT Tommy Reese 267 yds. | PIT Jay Dillon 113 yds. | PIT Nick Hill 97 yds. |
| Sat, Nov. 27 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TEN 33 at LV 20 | Final | TEN Chance Wharden 334 yds. | TEN R.J. Cash 131 yds. | TEN Josiah Price 128 yds. |
| Sun, Nov. 28 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ATL 28 at NY 27 | Final | ATL Ryan Glassman 287 yds. | ATL Chris L. Tucker 113 yds. | ATL Mike Martinez 110 yds. |
| CAR 24 at WAS 21 | Final | CAR Dale Gooden 212 yds. | CAR Paul Perkins 47 yds. | CAR Paul Perkins 63 yds. |
| TB 31 at MIA 30 | Final | TB Calvin Ayre 317 yds. | TB Cedric Miles 94 yds. | TB Otis Glendale 114 yds. |
| BRO 11 at BAL 24 | Final | BAL Randy Carlysle 222 yds. | BAL Tim Harper 71 yds. | BAL Charles Hunt 83 yds. |
| PHI 14 at CIN 40 | Final | CIN Kevin Hogan 424 yds. | CIN Kenyon Barnes 129 yds. | CIN J.J. Jefferson 186 yds. |
| KC 36 at STL 18 | Final | KC Thaddeus Lewis 349 yds. | KC Jordan Morris 97 yds. | KC Kevin Kroger 128 yds. |
| ARI 30 at NO 34 | Final | NO Chris Coy 310 yds. | NO Austin Thomas 141 yds. | NO Jayson Lee 122 yds. |
| COL 22 at HOU 14 | Final | COL Hector Knoles 218 yds. | COL Omni Wells 77 yds. | COL David Davis 63 yds. |
| CAL 40 at SEA 19 | Final | CAL Travis Wilson 335 yds. | CAL Micah Mason 172 yds. | CAL Courtney Smith 150 yds. |
| MIN 20 at LA 31 | Final | LA Rayce Dawson 302 yds. | LA Rashard Jackson 108 yds. | LA Jai Williams 126 yds. |
| CHI 17 at BOS 35 | Final | BOS Vance Becker 326 yds. | BOS Vance Becker 41 yds. | BOS Brian Lee 152 yds. |
| Mon, Nov. 29 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BUF 28 at IND 27 | Final | BUF Travis Colin 256 yds. | BUF Justin Jonas 81 yds. | BUF Marcus Floyd 76 yds. |
| Week 13 | ||||
| Thu, Dec. 2 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CAL 35 at SD 31 | Final | CAL Travis Wilson 328 yds. | CAL Micah Mason 137 yds. | CAL David Wesley 139 yds. |
| Sat, Dec. 4 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIL 35 at MIN 34 | Final | MIL Richard Adams 332 yds. | MIL Kay'Ron Adams 128 yds. | MIL Matt Adams 114 yds. |
| Sun, Dec. 5 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| WAS 24 at NY 23 | Final | WAS Andrew Miller 214 yds. | WAS Justice Hill 82 yds. | WAS Marcus Kemp 74 yds. |
| CIN 22 at BRO 7 | Final | CIN Kevin Hogan 226 yds. | CIN Kenyon Barnes 63 yds. | CIN J.J. Jefferson 78 yds. |
| HOU 0 at MIA 35 | Final | MIA Adam Murray 319 yds. | MIA Darnell Sullivan 113 yds. | MIA Gary Jennings 117 yds. |
| PHI 27 at CLE 17 | Final | PHI Sylvester James 291 yds. | PHI Delious Childs 66 yds. | PHI Cookie Wallace 108 yds. |
| DET 49 at TEN 17 | Final | DET Brandon Peters 412 yds. | DET Gary Brightwell 153 yds. | DET Patrick Allen 167 yds. |
| IND 30 at CHI 10 | Final | IND Austin McNiel 363 yds. | IND Andre Duncan 148 yds. | IND Roy Roberts 154 yds. |
| CAR 8 at NO 20 | Final | NO Chris Coy 222 yds. | NO Austin Thomas 67 yds. | NO Jacob Mallory 59 yds. |
| TB 27 at STL 17 | Final | TB Calvin Ayre 267 yds. | TB Cedric Miles 51 yds. | TB Otis Glendale 128 yds. |
| ATL 17 at KC 27 | Final | KC Thaddeus Lewis 266 yds. | KC Jordan Morris 104 yds. | KC Kevin Kroger 116 yds. |
| COL 10 at ARI 28 | Final | ARI Jon Fallon 262 yds. | ARI Otis Harper 117 yds. | ARI Marvin MacDonald 125 yds. |
| DAL 24 at SEA 14 | Final | DAL Adam Froman 271 yds. | DAL Jevon Jones 83 yds. | DAL Antonio Tucker 97 yds. |
| LA 42 at LV 27 | Final | LA Rayce Dawson 414 yds. | LA Rashard Jackson 137 yds. | LA Taiwan Jones 142 yds. |
| BUF 20 at PIT 22 | Final | PIT Tommy Reese 261 yds. | PIT Jay Dillon 60 yds. | PIT Nick Hill 74 yds. |
| Mon, Dec. 6 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 20 at BOS 21 | Final | BOS Vance Becker 226 yds. | BOS Wesley Matthews 40 yds. | BOS Brian Lee 67 yds. |
| Week 14 | ||||
| Thu, Dec. 9 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LV 20 at PIT 31 | Final | PIT Tommy Reese 318 yds. | PIT Jay Dillon 76 yds. | PIT Brian Curtis 118 yds. |
| Sat, Dec. 11 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| KC 28 at DET 30 | Final | DET Brandon Peters 296 yds. | DET Gary Brightwell 134 yds. | DET Patrick Allen 126 yds. |
| Sun, Dec. 12 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIN 28 at BOS 27 | Final | MIN Thomas Kaye 256 yds. | MIN Charles Hyder 99 yds. | MIN Domino Jenkins 97 yds. |
| LA 30 at MIA 34 | Final | MIA Adam Murray 263 yds. | MIA Darnell Sullivan 134 yds. | MIA Devin Youngblood 87 yds. |
| NY 29 at PHI 27 | Final | NY Scott Tolzner 289 yds. | NY Sherwood Brown 116 yds. | NY Deagen Motts 84 yds. |
| TB 41 at CAR 15 | Final | TB Calvin Ayre 363 yds. | TB Cedric Miles 104 yds. | TB Jailyn Marshall 148 yds. |
| WAS 17 at CLE 27 | Final | CLE John Locke 301 yds. | CLE Kelvin Diggs 75 yds. | CLE Pharoah Brown 184 yds. |
| SD 38 at CIN 7 | Final | SD Douglas Knotts 317 yds. | SD Earl Wregget 122 yds. | SD Earl Wregget 129 yds. |
| DAL 28 at ATL 34 | Final | ATL Ryan Glassman 339 yds. | ATL Chris L. Tucker 104 yds. | ATL Dominique Worthy 126 yds. |
| STL 0 at NO 24 | Final | NO Chris Coy 247 yds. | NO Austin Thomas 118 yds. | NO Jayson Lee 81 yds. |
| BRO 17 at TEN 38 | Final | TEN Chance Wharden 387 yds. | TEN R.J. Cash 146 yds. | TEN James Roe 175 yds. |
| CAL 37 at HOU 20 | Final | CAL Travis Wilson 328 yds. | CAL Micah Mason 179 yds. | CAL Courtney Smith 156 yds. |
| MIL 45 at COL 17 | Final | MIL Richard Adams 409 yds. | MIL Kay'Ron Adams 148 yds. | MIL Greg Chatham 217 yds. |
| IND 27 at SEA 31 | Final | SEA Brandon Morris 302 yds. | SEA Bennett James 77 yds. | SEA Tyler Lockett 106 yds. |
| CHI 24 at ARI 37 | Final | ARI Jon Fallon 376 yds. | ARI Otis Harper 131 yds. | ARI Marvin MacDonald 124 yds. |
| Mon, Dec. 13 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BUF 24 at BAL 20 | Final | BUF Travis Colin 252 yds. | BUF Justin Jonas 139 yds. | BUF Justin Jonas 118 yds. |
| Week 15 | ||||
| Thu, Dec. 16 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| ARI 28 at CAL 27 | Final | ARI Jon Fallon 267 yds. | ARI Otis Harper 83 yds. | ARI Kirby Moore 97 yds. |
| Sat, Dec. 18 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| IND 33 at PIT 27 | Final | IND Austin McNiel 362 yds. | IND Andre Duncan 136 yds. | IND Roy Roberts 202 yds. |
| Sun, Dec. 19 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CLE 22 at BRO 17 | Final | CLE John Locke 226 yds. | CLE Kelvin Diggs 63 yds. | CLE Alex Johnson 78 yds. |
| NO 21 at NY 6 | Final | NO Chris Coy 232 yds. | NO Austin Thomas 87 yds. | NO Jayson Lee 93 yds. |
| BOS 17 at MIA 30 | Final | MIA Adam Murray 346 yds. | MIA Darnell Sullivan 129 yds. | MIA Devin Youngblood 118 yds. |
| TEN 20 at WAS 29 | Final | WAS Andrew Miller 233 yds. | WAS Justice Hill 120 yds. | WAS Justice Hill 86 yds. |
| MIL 31 at BAL 30 | Final | MIL Richard Adams 330 yds. | MIL Kay'Ron Adams 97 yds. | MIL Greg Chatham 126 yds. |
| ATL 13 at TB 33 | Final | TB Calvin Ayre 349 yds. | TB Cedric Miles 118 yds. | TB Jailyn Marshall 136 yds. |
| CHI 21 at CIN 17 | Final | CHI Ryan Gable 262 yds. | CHI Duane Banks 75 yds. | CHI Elliott Boone 81 yds. |
| LV 23 at MIN 27 | Final | MIN Thomas Kaye 246 yds. | MIN Charles Hyder 74 yds. | MIN Kendall Price 103 yds. |
| CAR 26 at STL 7 | Final | CAR Dale Gooden 242 yds. | CAR Dale Gooden 89 yds. | CAR Dale Gooden 87 yds. |
| PHI 7 at DAL 27 | Final | DAL Adam Froman 261 yds. | DAL Jevon Jones 107 yds. | DAL Antonio Tucker 89 yds. |
| HOU 10 at KC 41 | Final | KC Thaddeus Lewis 391 yds. | KC Jordan Morris 172 yds. | KC Andrew Pierce 186 yds. |
| COL 10 at LA 36 | Final | LA Rayce Dawson 367 yds. | LA Rashard Jackson 105 yds. | LA Taiwan Jones 128 yds. |
| SEA 28 at SD 24 | Final | SEA Brandon Morris 260 yds. | SEA Bennett James 95 yds. | SEA Anthony Jones 92 yds. |
| Mon, Dec. 20 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 34 at BUF 20 | Final | DET Brandon Peters 319 yds. | DET Gary Brightwell 136 yds. | DET Patrick Allen 108 yds. |
| Week 16 | ||||
| Thu, Dec. 23 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LV 17 at LA 36 | Final | LA Rayce Dawson 338 yds. | LA Rashard Jackson 126 yds. | LA Jayar Jackson 153 yds. |
| Fri, Dec. 24 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CHI 28 at IND 33 | Final | IND Austin McNiel 322 yds. | IND Andre Duncan 166 yds. | IND Roy Roberts 141 yds. |
| Sat, Dec. 25 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 38 at MIL 27 | Final | DET Brandon Peters 369 yds. | DET Gary Brightwell 59 yds. | DET Gary Brightwell 182 yds. |
| Sun, Dec. 26 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BOS 8 at BRO 21 | Final | BRO Matt Johnson 249 yds. | BRO Matt Johnson 57 yds. | BRO Harold Jennings 92 yds. |
| NY 21 at WAS 17 | Final | NY Scott Tolzner 263 yds. | NY Sherwood Brown 77 yds. | NY Draymond Blackshear 96 yds. |
| CLE 30 at PHI 31 | Final | PHI Sylvester James 256 yds. | PHI Delious Childs 65 yds. | PHI Delious Childs 111 yds. |
| STL 21 at TB 34 | Final | TB Calvin Ayre 362 yds. | TB Cedric Miles 161 yds. | TB Otis Glendale 126 yds. |
| NO 17 at CAR 26 | Final | CAR Dale Gooden 272 yds. | CAR Paul Perkins 169 yds. | CAR Paul Perkins 108 yds. |
| KC 35 at ATL 20 | Final | KC Thaddeus Lewis 328 yds. | KC Jordan Morris 170 yds. | KC Andrew Pierce 165 yds. |
| PIT 10 at CIN 49 | Final | CIN Kevin Hogan 527 yds. | CIN Kenyon Barnes 139 yds. | CIN J.J. Jefferson 208 yds. |
| MIN 20 at BUF 24 | Final | BUF Travis Colin 234 yds. | BUF Justin Jonas 114 yds. | BUF Marcus Floyd 95 yds. |
| ARI 21 at DAL 41 | Final | DAL Adam Froman 418 yds. | DAL Jevon Jones 152 yds. | DAL Antonio Tucker 173 yds. |
| MIA 28 at HOU 24 | Final | MIA Adam Murray 252 yds. | MIA Darnell Sullivan 76 yds. | MIA Gary Jennings 83 yds. |
| SEA 26 at COL 21 | Final | SEA Brandon Morris 229 yds. | SEA Bennett James 71 yds. | SEA Tyler Lockett 86 yds. |
| SD 24 at CAL 36 | Final | CAL Travis Wilson 387 yds. | CAL Micah Mason 189 yds. | CAL David Wesley 161 yds. |
| Mon, Dec. 27 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| TEN 28 at BAL 17 | Final | TEN Chance Wharden 374 yds. | TEN R.J. Cash 149 yds. | TEN Kris Thompkins 128 yds. |
| Week 17 | ||||
| Thu, Dec. 30 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| SEA 18 at TB 27 | Final | TB Calvin Ayre 270 yds. | TB Cedric Miles 143 yds. | TB Otis Glendale 89 yds. |
| Fri, Dec. 31 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 30 at CLE 17 | Final | DET Brandon Peters 414 yds. | DET Gary Brightwell 139 yds. | DET Patrick Allen 162 yds. |
| Sat, Jan. 1 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIL 42 at PIT 24 | Final | MIL Richard Adams 426 yds. | MIL Kay'Ron Adams 133 yds. | MIL Matt Adams 154 yds. |
| Sun, Jan. 2 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NY 20 at BOS 38 | Final | BOS Vance Becker 377 yds. | BOS Vance Becker 68 yds. | BOS Howard Jenkins 214 yds. |
| TEN 42 at BRO 6 | Final | TEN Chance Wharden 428 yds. | TEN R.J. Cash 167 yds. | TEN James Roe 133 yds. |
| CAR 28 at MIA 3 | Final | CAR Dale Gooden 243 yds. | CAR Paul Perkins 81 yds. | CAR Kijan Walker 76 yds. |
| IND 17 at PHI 20 | Final | PHI Sylvester James 229 yds. | PHI Delious Childs 69 yds. | PHI Cookie Wallace 83 yds. |
| STL 12 at CIN 31 | Final | CIN Kevin Hogan 371 yds. | CIN Kenyon Barnes 129 yds. | CIN J.J. Jefferson 178 yds. |
| BUF 27 at MIN 13 | Final | BUF Travis Colin 301 yds. | BUF Justin Jonas 92 yds. | BUF Marcus Floyd 143 yds. |
| NO 28 at KC 24 | Final | NO Chris Coy 265 yds. | NO Austin Thomas 111 yds. | NO Jayson Lee 77 yds. |
| BAL 22 at HOU 23 | Final | HOU De'Andre Johnson 240 yds. | HOU Milo Hall 73 yds. | HOU Jordan Higgins 61 yds. |
| WAS 20 at COL 22 | Final | COL Hector Knoles 224 yds. | COL Omni Wells 80 yds. | COL Omni Wells 68 yds. |
| ATL 13 at SD 34 | Final | SD Douglas Knotts 360 yds. | SD Earl Wregget 131 yds. | SD Wallace Poole 137 yds. |
| CAL 38 at LV 17 | Final | CAL Travis Wilson 338 yds. | CAL Micah Mason 136 yds. | CAL Courtney Smith 141 yds. |
| CHI 29 at DAL 22 | Final | CHI Ryan Gable 312 yds. | CHI Duane Banks 83 yds. | CHI B.J. MacIntyre 96 yds. |
| Mon, Jan. 3 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LA 30 at ARI 28 | Final | LA Rayce Dawson 297 yds. | LA Rashard Jackson 101 yds. | LA Jai Williams 90 yds. |
| Week 18 | ||||
| Thu, Jan. 6 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| DET 34 at IND 17 | Final | DET Brandon Peters 339 yds. | DET Gary Brightwell 125 yds. | DET Patrick Allen 119 yds. |
| Fri, Jan. 7 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CLE 30 at NY 20 | Final | CLE John Locke 322 yds. | CLE Kelvin Diggs 97 yds. | CLE Alex Johnson 118 yds. |
| Sat, Jan. 8 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BAL 28 at BRO 14 | Final | BAL Randy Carlysle 262 yds. | BAL Tim Harper 73 yds. | BAL Charles Hunt 75 yds. |
| PIT 23 at BUF 27 | Final | BUF Travis Colin 267 yds. | BUF Justin Jonas 118 yds. | BUF Justin Jonas 122 yds. |
| LA 34 at CAL 28 | Final | LA Rayce Dawson 337 yds. | LA Rashard Jackson 108 yds. | LA Jayar Jackson 119 yds. |
| CHI 17 at MIL 26 | Final | MIL Richard Adams 244 yds. | MIL Kay'Ron Adams 76 yds. | MIL Greg Chatham 103 yds. |
| Sun, Jan. 9 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| PHI 23 at WAS 24 | Final | WAS Andrew Miller 261 yds. | WAS Justice Hill 82 yds. | WAS Marcus Kemp 86 yds. |
| STL 27 at MIA 11 | Final | STL Kyle Allen 263 yds. | STL Kyle Allen 56 yds. | STL Kennedy Lewis 70 yds. |
| KC 41 at CAR 27 | Final | KC Thaddeus Lewis 386 yds. | KC Jordan Morris 177 yds. | KC Andrew Pierce 148 yds. |
| NO 30 at ATL 20 | Final | NO Chris Coy 274 yds. | NO Austin Thomas 63 yds. | NO Jacob Mallory 109 yds. |
| MIN 31 at CIN 20 | Final | MIN Thomas Kaye 308 yds. | MIN Charles Hyder 123 yds. | MIN Kendall Price 122 yds. |
| BOS 20 at TEN 28 | Final | TEN Chance Wharden 271 yds. | TEN R.J. Cash 134 yds. | TEN James Roe 92 yds. |
| COL 20 at DAL 51 | Final | DAL Adam Froman 414 yds. | DAL Jevon Jones 151 yds. | DAL Antonio Tucker 173 yds. |
| TB 41 at HOU 24 | Final | TB Calvin Ayre 444 yds. | TB Cedric Miles 63 yds. | TB Otis Glendale 196 yds. |
| LV 29 at SD 22 | Final | LV Brett Smith 275 yds. | LV Ise Smith 113 yds. | LV Jamal Weekes 81 yds. |
| ARI 30 at SEA 38 | Final | SEA Brandon Morris 326 yds. | SEA Bennett James 128 yds. | SEA Anthony Jones 114 yds. |
| 2021 AFL POST SEASON SCHEDULE |
||||
| Wild Card Round | ||||
| Sat, Jan. 15 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CLE 19 at DAL 26 | Final | CLE John Locke 310 yds. | CLE Kelvin Diggs 83 yds. | DAL Antonio Tucker 116 yds. |
| SD 17 at LA 47 | Final | LA Rayce Dawson 308 yds. | LA Rashard Jackson 81 yds. | LA Jayar Jackson 89 yds, |
| Sun, Jan. 16 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| BOS 15 at BUF 31 | Final | BUF Travis Colin 271 yds. | BUF Justin Jonas 53 yds. | BUF Marcus Floyd 117 yds. |
| CAL 23 at TB 17 | Final | TB Calvin Ayre 254 yds. | CAL Micah Mason 96 yds. | TB Otis Glendale 69 yds. |
| ARI 21 at PHI 42 | Final | PHI Sylvester James 404 yds. | PHI Delious Childs 61 yds. | PHI Cookie Wallace 108 yds. |
| Mon, Jan. 17 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| MIL 11 at NO 34 | Final | NO Chris Coy 202 yds. | NO Austin Thomas 58 yds. | NO Jacob Mallory 61 yds. |
| Divisional Round | ||||
| Sat, Jan. 22 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| CAL 19 at TEN 16 | Final | CAL Travis Wilson 348 yds. | TEN R.J. Cash 66 yds. | TEN James Roe 142 yds. |
| NO 13 at DAL 10 | Final | DAL Adam Froman 225 yds. | NO Austin Thomas 53 yds. | DAL Antonio Tucker 129 yds. |
| Sun, Jan. 23 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| LA 30 at BUF 27 | Final | LA Rayce Dawson 366 yds. | BUF Justin Jonas 51 yds. | LA Taiwan Jones 183 yds. |
| PHI 36 at DET 42 | Final (ot) | DET Brandon Peters 378 yds. | DET Brandon Peters 69 yds. | PHI Cookie Wallace 201 yds. |
| Conference Championships | ||||
| Sun, Jan. 30 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NO 27 at DET 24 | Final (ot) | DET Brandon Peters 275 yds. | NO Austin Thomas 88 yds. | NO Jayson Lee 103 yds. |
| CAL 17 at LA 20 | Final | LA Rayce Dawson 337 yds. | LA Rashard Jackson 48 yds. | LA Jayar Jackson 142 yds. |
| Super Bowl XXXVIII | ||||
| Sun, Feb. 6 | Time (ET) | Top Passer | Top Rusher | Top Receiver |
| NO 23 at LA 44 | Final | LA Rayce Dawson 344 yds. | LA Rashard Jackson 77 yds. | LA David Tyrell 136 yds. |